Blood-Brain Barrier in Drug Discovery. Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs #927106
- Di Li; Kerns Edward H.
- Медицина. Здоровье; Фармакология. Фармакодинамика. Фармакокинетика
- John Wiley & Sons Limited (prof) EUR
- PDF книга
- 607 стр
- John Wiley & Sons Limited
Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery. • Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects • Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies • Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes • Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK) • Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market