Oral Bioavailability Assessment. Basics and Strategies for Drug Discovery and Development #931862

Авторы:
;
Жанры:
Медицина. Здоровье; Фармакология. Фармакодинамика. Фармакокинетика
Агент:
John Wiley & Sons Limited (prof) EUR
Формат:
PDF книга
Объем:
455 стр
Язык:
английский
Правообладатель:
John Wiley & Sons Limited
Аннотация:

Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development. • Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability • Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development • Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development • Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS) • Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development

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